Work

147 as a Novel Therapeutic Agent to Ameliorate Liver Ischemia-Reperfusion Injury via Protective Effects on Hepatocytes and Macrophages

Year: 2025

Type: article

Abstract: Purpose: The development of practical drugs to suppress ischemia-reperfusion injury (IRI) in liver transplantation (LT) is urgently needed. J147 is an analog of curcumin, a compound found in turmeric, but synthesized with better stability/bioavailability. It is being developed as a potential drug for the treatment of Alzheimer's disease. Since a recent study reported its beneficial effect on ischemic stroke in a rat cerebral infarction model, we investigated the potential effect of J147 pretreatment on an LT-related IRI in mice.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.1308

Authors: S. Yao, K. Dery, F. Kaldas, D. Farmer, E. Villafranca, J. Kupiec-Weglinski

Institution: University of California, Los Angeles

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300