Work

Proteomic Analysis of Perfusate from Normothermic Machine Perfusion of Human Livers Suggests Markers Associated with Organ Recovery

Year: 2025

Type: article

Abstract: Purpose: Normothermic machine perfusion (NMP) offers advantages over static cold storage (SCS), including reduction of hyperfibrinolysis and inflammation, and repletion of glycogen and ATP levels, particularly in steatotic or donation-after-circulatory-death livers. We hypothesized that the perfusate collected during NMP of human livers allows for capturing molecular markers indicative of regeneration of hepatocytes and cholangiocytes during organ recovery.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.2317

Authors: T. Sigdel, J. Kim, S. Syed, J. Bornstein, N. Sajai, B. Wang, C. Freise, H. Willenbring, G. Roll

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300

OpenAlex ID: W4412850845

FWCI:

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