Interplay of Inflammation, Dysregulated Angiogenesis, and Coronary Microvascular Dysfunction Among Patients Being Evaluated for Kidney Transplant
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: Coronary microvascular dysfunction (CMD) is common in chronic kidney disease (CKD) and associated with excess cardiovascular risk. However, the underlying pathobiology of CMD is not fully understood. We hypothesized that proteomic biomarkers of CKD-related inflammation and dysregulated angiogenesis would correlate with CMD as assessed by myocardial flow reserve (MFR, calculated as the ratio of stress over rest myocardial blood flow) on cardiac positron emission tomography (PET) in patients being evaluated for kidney transplant.
Authors: D.M. Huck, B. Schreiber, B.N. Weber, J.M. Brown, S. Divakaran, M. A. Pabon Porras, L. Barrett, A. Sun, J. Hainer, R. Blankstein, S. Dorbala, E. Aikawa, A. Chandraker, M.F. Di Carli
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412851073