Long Term Enhanced Subnormothermic Machine Perfusion of Discarded Human and Porcine Kidney Grafts
Year: 2025
Type: article
Abstract: Purpose: Standard clinical methods for preserving kidney grafts include static cold storage (SCS) and hypothermic machine perfusion. Given the limited outcomes and high discard rates of donation after circulatory death (DCD) kidneys, this study evaluates the feasibility of extended subnormothermic machine perfusion (SNMP) in preserving graft viability and minimizing ischemic injury. The study compares DCD pig grafts stored for 24h with SNMP and SCS groups (n=3, each). Further, the model was replicated with discarded human kidney grafts (n=3) for extended durations up to 33h.
Authors: M. Hassan, M. Taggart, A. Lyon, C. Taveras, O. Ozgur, A. Cutrone, K. Uygun, A. Longchamp
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412851076