Work

Intracellular Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties during Antibody-Mediated Rejection

Year: 2025

Type: article

Abstract: Purpose: The pro-inflammatory effects of membrane attack complexes (MACs) are widely attributed to their abilities to cause cell death. Based on the large, de novo protein burden imposed by MACs on target cells and the intrinsic propensity of its components to oligomerize, we tested an alternate hypothesis that MACs may form non-cytolytic protein aggregates causing endothelial cell (EC) activation.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.193

Authors: Z. Ma, L. He, M. Mak, G. Moeckel, G. Tellides, D. Jane-Wit

Institution: Yale University

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300