Mosaic Loss of Y Chromosome in Proximal Tubular Cells is Associated with Recovery from DGF Post DCD Kidney Transplantation: A New Single Nucleus RNA-Seq Signature of Organ Quality
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: One fifth of the kidneys procured for transplantation in the US are discarded. Identification of kidneys with sufficient functional reserve at the time of procurement may increase the number of kidneys transplanted. We hypothesized that single-cell RNA-seq analysis of allograft biopsies obtained at time 0, 1 and 12 months will identify a signature of functional reserve predictive of successful graft function in marginal organs and thus minimize discard rates.
Authors: A. Malone, A. Leckie-Harre, A. Asthana, R. Paul, C. Jay, A. Farney, E. McCracken, R. Stratta, C. Webb, B. Humphreys, G. Orlando
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412851361