sCD14 as a Novel Biomarker for AKI in Deceased Kidney Donors
Year: 2025
Type: article
Abstract: Purpose: Kidney transplant is the best long-term treatment for end-stage kidney disease, but long wait times have led to using kidney donors with terminal acute kidney injury (AKI). Peri-mortem AKI a major cause of organ discard. Our lab has already already shown that toll-like receptors (TLRs) 2 and 4 activate the intracellular NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in renal tubule epithelium during experimental AKI. TLR recognition of DAMPs requires engagement by the coreceptor CD14.
Authors: S. Almeida, W. Snyder, M. Shah, A. Hawkes, S. DeWolf, J. Fisher, D. McKay
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412851402