Influence of the Blockage of TNFα and Its Receptors on Bregs-TLR-Induced Allograft Survival
Year: 2025
Type: article
Abstract: Purpose: Previous studies from the laboratory have shown that regulatory B cells induced ex-vivo via TLR4/9 signaling (Bregs-TLR) suppressed naïve B and T cell proliferation. Transferred TNF-α-/- Bregs-TLR failed to promote islet allograft survival in any recipients. Given the importance of TNF-α and its receptors (CD120a/CD120b) in tissue inflammation and its involvement in immunoregulatory pathways, the present study aims at evaluating the importance of TNF-α/CD120a/CD120b axis in Bregs-TLR-induced allograft survival.
Authors: Q. Fu, Q. Wu, Y. Yuan, G. Zhao, H. Yang, C. Leguern, J. Markmann
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852038