Work

Prediction Power of CIITA RNA Editing in Kidney Transplantation Outcomes

Year: 2025

Type: article

Abstract: Purpose: RNA editing is a post-transcriptional mechanism that alters RNA sequences, affecting RNA stability and regulating immune responses. While dysregulation of RNA editing has been linked to diseases like cancer and autoimmune disorders, its role in organ transplantation is still poorly understood. The ADAR enzyme, which mediates RNA editing, modifies double-stranded RNA by converting adenosine (A) to inosine (I), altering RNA structure, and dampening interferon-gamma (IFN-γ) signaling. Given that CIITA is induced by IFN-γ and is the major regulator of HLA class II expression and immune activation in transplantation, we investigated whether ADAR-mediated RNA editing of CIITA is a biomarker for kidney allograft rejection (Fig.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.680

Authors: G. Taborda Ribas, T.J. Borges, C. Riella, L. Riella

Institutions: Massachusetts General Hospital, Beth Israel Deaconess Medical Center

Language: English

Topic: RNA regulation and disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300