Characterizing the Relationship Between T Cell of Operational Tolerance (TOT) Cells and Regulatory T Cells (Tregs) in Pediatric Solid Organ Transplantation
Year: 2025
Type: article
Abstract: Purpose: Achieving allograft health while minimizing chronic immunosuppression remains a challenge in pediatric solid organ transplantation. Regulatory T cells (Tregs) are key mediators of immune tolerance in organ transplantation. A subpopulation of CD4 T cells (CD45RA-, CD25+, CD5+, CD38-), termed T Cell of Operational Tolerance (TOT) cells, has been significantly associated with stable graft function in both pediatric kidney transplant recipients and operational tolerant pediatric liver transplant recipients.
Authors: W. Zhang, M. Rao, M. Amouzgar, A. Reitsma, J.K. Pena, P. Nova, A. Shah, S. Bendall, C. Esquivel, O. Martinez, S. Krams
Institutions: Stanford Medicine, Stanford University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852155