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Early Reporting of Transplant Rejection: Genetically Engineered ‘Smart-Organs’ Featuring Diagnostic Capabilities

Year: 2025
Type: article
Abstract: Purpose: Early detection of organ transplant rejection is hindered by limitations of existing diagnostic tools. Current blood tests lack sensitivity and specificity, while biopsies remain invasive. To address these challenges, this study explores a novel approach that combines gene therapy and machine perfusion to enable long-term genetic modification and, subsequently, non-invasive and early detection of rejection in transplanted organs.
DOI: 10.1016/j.ajt.2025.07.047
Authors: R. Bento, I. Filz von Reiterdank, A.T. Dinicu, C. Taveras, M. Hassan, M. Mojoudi, H. Chen, B. Ellis, G. Wojtkiewicz, R. Weissleder, B. Uygun, C.L. Curtis L. Cetrulo, J. Coert, A.B. Mink van der Molen, B. Parekkadan, K. Uygun
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852258
FWCI:
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