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Comprehensive Long-Read Whole Genome Sequencing in 7 Human Xenotransplant Recipients

Year: 2025

Type: article

Abstract: Purpose: Wholegenome sequencing (WGS) is emerging as a powerful tool for identifyingmedically actionable genetic variants in human transplant recipients that caninfluence primary disease management and medication selection. By enablingcomprehensive detection of human pathogenic American College of MedicalGenetics and Genomics (ACMG) ‘medically actionable’ variants and clinicallyactionable pharmacogenomic (PGx) markers, WGS enhances precision medicinestrategies in human transplant recipients optimizing post-transplant care.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.053

Authors: K. Moi, M. Rophina, S. Williams, S. Vikman, K. Khalil, R. Esker, E. Weldon, A. Mattoo, V. Tatapudi, D. Argibay, Z. Zayas, S. Eloi, A. Griesemer, J. Stern, R. Montgomery, B. Keating

Language: English

Topic: Xenotransplantation and immune response

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300

OpenAlex ID: W4412852269

FWCI:

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