Adenosine, a Key Regulator of Human Pancreatic Islet Insulin Content and a Shield Against Hypoxia Injury
Year: 2025
Type: article
Abstract: Purpose: Islet transplantation is an effective cell therapy for treating type 1 diabetes. However, a high therapeutic dose is required to achieve optimal glycemic control, as a significant proportion of islets is destroyed shortly post-transplantation due to oxidative stresses. Adenosine has been shown to decrease the metabolism of rat islets and, also to provide protection against ischemia-reperfusion injury. Therefore, the objective was to assess the impact of adenosine in preventing hypoxia-associated adverse effects on human islets viability and function.
Authors: Q. Perrier, L. Byers, W. Jeong, E. Peveri, R. Bottino, C. Fraker, A. Tomei, A. Asthana, G. Orlando
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852505