Rapid Hepatic Defatting for Transplant by Knocking Down tPA Using Lipid Nanoparticles
Year: 2025
Type: article
Abstract: Purpose: Liver transplant is the sole curative treatment for end-stage liver disease. However, the demand for liver transplants exceeds the available organs, which results in a substantial waiting list and high mortality rates. Marginal grafts are currently underutilized due to the risk of graft failure from ischemia-reperfusion injury. Strategies capable of modifying marginal livers to improve their viability for transplant have potential to significantly mitigate organ shortages.
Authors: K. Badior, H. Turner, M. Kim, S. Hong, W. Lee, S. Kumar, Z. Zheng, J. Kim, C. Kastrup
Institution: Medical College of Wisconsin
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852552