Normothermic Machine Perfusion Mitigates Allograft Inflammation in Intestinal Transplantation
Year: 2025
Type: article
Abstract: Purpose: Transplantation is life-saving for intestinal failure patients who no longer tolerate parenteral nutrition. Intestinal transplantation (IT) following traditional allograft static cold storage (CS) frequently results in rejection. Improved transplant outcomes of other solid organ have been achieved using normothermic machine perfusion (NMP)-based storage, in part through allograft immune modulation. The exploration of NMP in IT is nascent. Preliminary assays demonstrate that NMP stabilizes intraepithelial lymphocytes in the small intestine while decreasing lamina propria natural killer cell populations at the end of storage.
Authors: L.M. Gonzalez, C. McKinney-Aguirre, E. Goya-Jorge, C. Schaaf, E. Ludwig, L. Poisson, J. Freund, N. Abraham, A. Hassan, T. Kaeser, M. DuBois, J. Blakeley-Ruiz, M. Kleiner, K. Garman, A. Barbas, D. Sudan
Institutions: North Carolina State University, Duke University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412852566