Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim: This study investigates the association of intraoperative variables, including anesthesia and cardiopulmonary bypass (CPB) durations, delta CO2 (ΔCO2), and lactate levels, with postoperative morbidity and mortality in neonates undergoing complex congenital cardiac surgery.Materials and Methods: A retrospective analysis was conducted on 42 neonates who underwent surgery in a single center.Data on demographic characteristics, genetic anomalies, anesthesia and CPB durations, and blood gas parameters (ΔCO2 and lactate levels at entry [T0], post-CPB [T1], and intensive care unit admission [T2]) were collected.Associations between these variables and major adverse events (MAEs) or mortality were statistically analyzed.Results: A total of 42 neonatal patients were included in the study.The median age of the patients was calculated as 0.4 ± 0.3 months.The mean weight of the sample was 3.3 ± 0.6 kg, and the median total anesthesia and CPB durations were 378.45 ± 103.67 and 116.86 ± 55.03 minutes, respectively.ΔCO2 levels at T0 were significantly associated with MAEs (p < 0.05), while elevated ΔCO2 at T0 and T1 was observed in patients who died.Total anesthesia duration was a significant predictor of both MAEs and mortality (p = 0.014).Lactate levels, however, showed no significant correlation with either MAEs or mortality at any time point.Discussion: Prolonged anesthesia and CPB durations, along with elevated ΔCO2 levels, are key predictors of adverse outcomes in neonates undergoing cardiac surgery.Delta CO2 may serve as an additional marker for early postoperative risk stratification.Larger prospective studies are warranted to confirm these findings and improve clinical management strategies.
DOI: 10.4328/acam.22505
Authors: Serife Ozalp, Erkut Ozturk
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412854369