Year: 2025
Type: article
Abstract: The encoded SOX13 gene from the HMG-box genes family is testis associated with the HMG-box domain bound with DNA. The HMG-box associated genes play a dominant role during the growth. Precisely, SOX13 is an insulin-dependent gene located on chromosome 1. The insulin is substantial proof of the genomics variance of the SOX13 gene illustrates the statement of sensibility in type-1 diabetes (T1D). SOX13 identified in islets also exocrine pancreas and initiated as a vital auto-antigen (ICA12). The beta-cell antigens stimulate the mechanisms of peripheral tolerance. The approval of the SOX13 gene as an auto-antigen is an effective marker for autoimmunity. So, I aimed to an analysis of SOX13 gene from the family of SRY-related HMG-box genes in the mammal. Therefore, I performed bioinformatics and computational application for experimentation of particular gene and their family in two different organisms. My finding provided a genomic variability of the SOX13 gene is sensitive in T1D. Therefore, I documented the SOX13 gene and their molecular mechanism and total HMG-box domains in Homo sapiens and Mus musculus. A computational and bioinformatics analysis demonstrated that SOX13 is an insulin-dependent gene. The series of reports suggested unique aspects of SRY-related HMG-box genes during the growth of organisms. My findings justified that the HMG-box genes play essential roles during the development of mammals. In contrast, the high mobility group (HMG-box) of the SOX13 is an insulin-dependent gene.
Source: Medical Research Archives
Author: Shouhartha Choudhury
Institution: Assam University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
Funder: Assam University, Silchar
OpenAlex ID: W4412861649