Assessing Hemopure Based Oxygenated Flushing in Liver Transplantation: A Bioenergetic Molecular Analysis Approach
Year: 2025
Type: article
Abstract: Purpose: Given the limited donor pool and the detrimental effects of ischemia during transplantation, optimizing preservation methods is crucial for improving graft function. Cold ischemia occurs during procurement, transportation, and preparation, followed by warm ischemia during implantation due to gradual temperature rise. These ischemic phases synergistically exacerbate ischemia-reperfusion injury (IRI). Hemopure (HBOC-201), a hemoglobin-based oxygen carrier, can enhance oxygen delivery compared to aqueous solutions.
Authors: A. Kharga, H. Chen, M. Taggart, M. Mojoudi, A. Longchamp, H. Yeh, K. Uygun, J. Markmann
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Award: G6604001345
OpenAlex ID: W4412866038