Year: 2024
Type: article
Abstract: Breast cancer was a health priority both globally and in Argentina, where it was the leading cause of death from tumours in women. Its molecular and genetic understanding has led to advances in diagnosis, prognosis and treatment. The luminal subtype, characterised by hormone receptors, and the PIK3CA gene mutation, involved in the PI3K/Akt/mTOR pathway, were highlighted as being associated with greater tumour aggressiveness and resistance to therapies. In Argentina, studies have shown a high prevalence of this mutation, prompting the use of targeted therapies such as Alpelisib. This personalised approach has improved the stratification and clinical management of the disease.
Source: South Health and Policy
DOI: 10.56294/shp2024400
Authors: Bruno Franco Santoro, Mónica Casalnuovo
Institution: Universidad Abierta Interamericana
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4412866202