Work

Generation and Characterization of a Novel Anti-IL-17A Monoclonal Antibody for the Treatment of Psoriatic Arthritis

Year: 2025

Type: article

Abstract: Interleukin-17A (IL-17A) plays a pivotal role in the pathogenesis of psoriatic arthritis. We generated a high-affinity monoclonal antibody against IL-17A using hybridoma technology and characterized its binding kinetics, neutralization potency, and in vivo efficacy in an experimental arthritis model. The antibody demonstrated superior affinity compared to existing therapeutics and significantly reduced disease severity in treated animals. These results support the potential of this novel antibody as a therapeutic candidate.

Source: Trends in Pharmaceutical Biotechnology

DOI: 10.57238/tpb.2025.153196.1027

Authors: Widad Abd AL Jabbar Mozzan, Nada Khazal K. Hindi, Ashwaq Al-jburi, Yasmeen Ali Hussein, Hayder Al-Aubaidy

Institutions: Al-Mustaqbal University, University of Babylon, University of Alkafeel

Language: English

Topic: Spondyloarthritis Studies and Treatments

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4412878417

FWCI: 0.643

Cites:

Cited by: 1

Related to: 10