Comparative efficacy of granulocyte colony stimulating factor and platelet-rich plasma on clinical pregnancy rates and endometrial outcomes in women undergoing frozen embryo transfer: a randomized controlled trial with 560 subjects
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective. Previous studies comparing granulocyte colony stimulating factor (GCSF) and platelet-rich plasma (PRP) in the context of frozen embryo transfer (FET) have yielded inconsistent results, largely due to a lack of robust randomized controlled trials (RCTs). This study aimed to assess the impact of intrauterine infusion of GCSF and PRP on clinical pregnancy rates and other reproductive outcomes in women undergoing FET, and to evaluate their effects on implantation rates and endometrial characteristics. Materials and method. This RCT included 560 women who were randomly assigned to receive 300 mcg GCSF, 1 ml PRP, or saline as a control. The intervention was administered into the uterine cavity via an intrauterine insemination catheter under ultrasound guidance. All participants underwent conventional hormonal therapy before the FET cycle. Endometrial evaluation was conducted using transvaginal ultrasound (TVUS), Doppler studies, and histological assessments in both natural and intervention cycles. Embryos were genetically tested prior to transfer. Results. The clinical pregnancy rates were similar across all groups (50.4% for GCSF, 51.2% for PRP, and 45.8% for saline; p=0.66). PRP administration significantly improved endometrial vascularity compared to saline (p=0.003); however, this did not translate into a higher clinical pregnancy rate. Live birth rates were also comparable among the groups (72.5% for GCSF and 75.6% for PRP). Conclusions. The study revealed that neither GCSF nor PRP influenced clinical pregnancy rates or overall pregnancy outcomes in women undergoing FET. While PRP improved endometrial vascularity, it did not affect the clinical pregnancy rates. Both interventions produced similar results to those using saline.
Source: Ginecologia ro
Author: Smit B. Solanki
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412892690