Year: 2025
Type: article
Abstract: The luteal phase, initiated after ovulation, is characterized by the secretion of progesterone by the corpus luteum, which is essential for preparing the endometrium for embryo implantation. Luteal phase stimulation (LPS) is a procedure used in assisted reproductive technologies (ART), including in vitro fertilization (IVF), oocyte donation and fertility treatments, to optimize the number of oocytes for poor responder patients. This method is useful for women with reduced ovarian reserve, increasing the number of oocytes retrieved, thus augmenting the chances of obtaining more embryos, improving the chances of successful embryo implantation. Studies comparing luteal phase stimulation to traditional follicular phase stimulation have shown that LPS may offer benefits for women with poor ovarian reserve or those undergoing fertility preservation. Additionally, dual ovarian stimulation (DuoStim), which combines follicular and luteal phase stimulation in the same cycle, has proven effective, improving pregnancy outcomes for poor responders as a result of increasing the number of oocytes and embryos obtained. Although LPS tends to require a longer duration and higher doses of gonadotropins, it has been associated with higher mature oocyte yields, though its cost-effectiveness and long-term clinical benefits, especially in poor responders, need further investigation.
Source: Ginecologia ro
Institution: Carol Davila University of Medicine and Pharmacy
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412892694