Work

Synthesis and Characterization of 2 methylindolizino[1,2 b]quinolin 9(11H) one

Year: 2025

Type: article

Abstract: Camptothecin is a natural quinoline alkaloid, initially extracted from the bark of the Chinese tree Camptotheca acuminata, which acts as a powerful anti-cancer agent by inhibiting DNA topoisomerase I. Number of Camptothecin analogs synthesized by researchers to find potent anticancer drug. Camptothecin drug having Quinoline and 2-pyrodone moiety in their structure have biological activity and their derivatives are used in number of drugs. In present work a Tetracyclic (ABCD) ring core of camptothecin was synthesized by simple method using simple starting material like aniline derivatives and 2-pyridone in six steps. The intermediates were confirmed and characterized by FT-IR, LC-MS and 1HNMR.

Source: Journal of Emerging Technologies and Innovative Research

DOI: 10.56975/jetir.v12i7.567484

Authors: Dr. Atul Kumar Kushwaha, Dr. F. Nawaz Khan

Institutions: Goswami Tulsidas Government Postgraduate College Karvi, Chitrakoot, Vellore Institute of Technology University

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Indian Institute of Technology Madras, VIT University