Integrating Bulk RNA and Single-cell transcriptome to explore the role of glycan-related genes in lung adenocarcinoma.
Year: 2025
Type: article
Abstract: Our study found that glycan-related genes could alter the composition of immune cell infiltration in LUAD tumor tissues and might affect the interaction between immune cells and tumor cells through intercellular section signals, resulting in the inability of immune cells to normally initiate immune responses against tumor cells. These findings offer new biological perspectives of glycan-related genes in shaping the TME and potential targets for personalized LUAD treatment.
Source: PubMed
DOI: 10.7150/jca.115989
Authors: Keyun Zhu, Changqing Yang, Guixin Wang, XingKai Wang, Chengbin Lin, Yingxi Li, Ningning He, Yao Tian, Weiyu Shen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4412901585