The glucose sensor NSUN2-m 5 C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution
Year: 2025
Type: article
Abstract: T cell dysfunction. Building on these insights, we designed a dual-targeting strategy combining GLUT1/NSUN2 axis inhibitor WZB117 with PD-L1 blockade, which synergistically suppressed tumor evolution and reversed immunosuppression in preclinical models, suggesting a novel synergistic therapeutic strategy for treatment-resistant HCC.
DOI: 10.7150/ijbs.115610
Authors: Jing He, Boqiang Liu, Weijun Zhao, Hao Shen, Yi Wang, Weiqi Li, Chenqi Jin, Yifan Wang, Xiujun Cai, Liang Shi
Institutions: Sir Run Run Shaw Hospital, Zhejiang University
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4412901755