Synergistic tumor microenvironment modulation enabled by a nanozyme-boosted biomimetic macrophage-derived nanovesicle for highly efficient antitumor therapy
Year: 2025
Type: article
Abstract: This study presents a novel nanozyme-boosted biomimetic macrophage-derived nanovesicle system that integrates precise tumor targeting, chemotherapy delivery, and TME immunomodulation. By repolarizing TAMs and enhancing antitumor immunity, the platform offers a promising strategy to overcome treatment resistance in immunosuppressive tumors. Its scalable production and high clinical potential make it a viable candidate for future cancer therapy applications.
Source: Theranostics
DOI: 10.7150/thno.114467
Authors: Yue Su, Haibin Wu, Ke Duan, Jiahao Xie, Weitao Huang, Xiaozhou Mou, Xiangming Ye, Yeyu Shen, Ting Li, Junjia He, Luoqin Fu, Yin Wang, Liping Wen, Qiong Bian, Mingang Zhu, Xiangmin Tong
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4412901940