Year: 2025
Type: article
Abstract: generated AAE-DTCs by salt metathesis with silver nitrate. The isolated products were characterised by different analytical techniques. Ag(L1), Ag(L4), and Ag(L5) were accessible to single-crystal X-ray structure determination, comprising hexameric subunits linked by dimeric units into a 1D-polymeric structure (Ag(L1)) and more homogeneous ribbon-like polymeric structures (Ag(L4) and Ag(L5)). DOSY NMR measurements and supporting DFT calculations were carried out to elucidate the structure of these compounds in solution, showing evidence for smaller agglomerates like dimers and tetramers. Additionally, as first evaluation of the biological activity of these complexes, ethidium bromide displacement assays and DNA melting curve experiments were carried out, the results showing moderate DNA binding abilities.
Source: Dalton Transactions
DOI: 10.1039/d5dt01476j
Authors: Vreni Behling, Jakob Heinrich, Dolores Díaz, Elias H. P. Brohmer, Julian Heinrich, Nils Schlörer, Stephan Kupfer, Nora Kulak, Phil Köhler
Institutions: Friedrich Schiller University Jena, University of Potsdam
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412907441