Work

Risk factors and prognosis of tuberculous pleural effusion in TB patients

Year: 2025

Type: preprint

Abstract: The objective of this study was to examine the epidemiological characteristics of Tuberculous pleural effusion (TPE) and to evaluate the risk factors and prognostic outcomes of TPE in patients diagnosed with tuberculosis (TB). The study included all TB patients admitted to Shanghai Pulmonary Hospital from January 2014 to December 2020. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for TPE, while univariate and multivariate Cox proportional hazards models were employed to assess prognostic factors. A total of 18,258 TB patients were enrolled in the study, of whom 1,665 had TPE. Univariate logistic regression analysis revealed that male gender (OR = 1.276; 95% CI: 1.146–1.420, p < 0.001), age ≥ 70 years (OR = 1.275; 95% CI: 1.100-1.479, p = 0.001), and a history of psychosis (OR = 2.565; 95% CI: 1.278–5.147, p = 0.008) were risk factors for TPE. Multivariate logistic regression analysis confirmed that male gender (OR = 1.284; 95% CI: 1.153–1.429, p < 0.001), age ≥ 70 years (OR = 1.280; 95% CI: 1.102–1.485, p = 0.001), and a history of psychosis (OR = 2.450; 95% CI: 1.217–4.903, p = 0.012) remained independent risk factors for TPE. Univariate Cox regression analysis indicated that age ≥ 70 years (HR = 6.114; 95% CI: 2.425–15.415, p < 0.001) and diabetes (HR = 5.072; 95% CI: 1.468–17.528, p = 0.010) were correlated with an increased risk of mortality in TPE patients. Conversely, Whole-course management reduced the risk of death (HR = 0.291; 95% CI: 0.109–0.776, p = 0.014). Multivariate Cox regression analysis further confirmed that age ≥ 70 years (HR = 5.207; 95% CI: 2.043–13.267, p < 0.001) and diabetes (HR = 3.530; 95% CI: 1.007–12.377, p = 0.049) were independent predictors of mortality, while Whole-course management remained protective (HR = 0.319; 95% CI: 0.119–0.853, p = 0.023). The study elucidated the epidemiological characteristics correlated with the risk and prognosis of TPE among TB patients in China.

Source: Research Square

DOI: 10.21203/rs.3.rs-7069448/v1