Work

Anomalous Origin of the Left Anterior Descending Artery From the Pulmonary Artery in an Infant With TMCO1 Mutation and Cohen Syndrome

Year: 2025

Type: article

Abstract: Anomalous left anterior descending coronary artery from the pulmonary artery (ALADAPA; Figure 1) is an exceedingly rare congenital cardiac anomaly with variable presentation, ranging from an asymptomatic murmur to sudden cardiac arrest, and can be a challenging condition to diagnose. In this report, we present the case of a 4-month-old infant with TMCO1 mutation and Cohen syndrome, found to have ALADAPA on screening echocardiography. This case confirms that imaging remains a critical component in the diagnosis and management of ALADAPA and helps provide a blueprint for early detection and treatment of the condition.

Source: CASE

DOI: 10.1016/j.case.2025.06.003

Authors: Rahul Mital, Yea-Lyn Pak, Daniel E. Nento, Harinder R. Singh, James P. Strainic, Arpit K. Agarwal

Institutions: Rainbow Babies & Children's Hospital, Case Western Reserve University

Language: English

Topic: Coronary Artery Anomalies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $950