Effect of Polyherbal Toothpaste on Dental Plaque, Gingivitis, and Salivary Antioxidant Levels: A Single-blind Randomized Controlled Trial
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: against reactive oxygen and nitrogen species.1,2,4 A systematic review concluded that in most of the studies, antioxidant status was higher in caries-active individuals and could be an adaptive response to increased oxidative stress.5 Most studies evaluated lipid peroxidase among patients with periodontitis. IntroductIonDental plaque is the main risk factor for oral diseases such as caries, gingivitis, and periodontitis.It deposits on the teeth and restoration alike sequentially with a complex biofilm structure interspersed with a variety of microorganisms and extracellular matrix.Hence, plaque control daily is imperative to prevent oral diseases.Selfcare plaque control involves the use of a toothbrush, toothpaste, appropriate technique, frequency, and duration of toothbrushing.Brushing with toothpaste helps reduce the dependency on mechanical plaque control methods as they have antimicrobial agents and other additives that may inhibit the growth of dental plaque.However, these antimicrobial agents have potential side effects on long-term usage.There has been increased availability and acceptance of herbal-based toothpastes among the consumers which led to the introduction of newer herbal extracts and polyherbal formulations in the commercially available products.The antimicrobial, antiinflammatory, and antioxidant properties of these products help in maintaining oral health.The oral cavity has a complex environment with constant interactions with microorganisms and environmental irritants which increase the production of reactive oxygen and nitrogen species.1,2 Higher levels can cause damage to proteins, lipids, and DNA, leading to changes in cellular metabolism known as oxidative stress.2,3 Saliva has a variety of substances such as catalase, peroxidase, glutathione reductase, uric acid, reduced glutathione, albumin, lactoferrin, and polyphenols which act 1,
Authors: Kalyana C Pentapati, Lahari Anand, Revathi P Shenoy, Geethika Yelleti, Saurabh Kumar
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412916885