Work

Chiral Phosphoric Acid‐Catalyzed Atroposelective Synthesis of Axially Chiral Aminophosphines

Year: 2025

Type: article

Abstract: Comprehensive Summary P,N ‐Atropisomers are valuable structural motifs, widely utilized as chiral ligands and in various catalytic systems. However, the asymmetric synthesis of these compounds from readily available starting materials remains a significant challenge. In this study, we present a chiral phosphoric acid‐catalyzed atroposelective synthesis of axially chiral aminophosphines via dynamic kinetic resolution. This approach effectively addresses the aforementioned challenge through featuring the use of readily available starting materials, mild reaction conditions, high yields, excellent enantioselectivities, and a broad substrate scope, underscoring its practicality and synthetic utility.

Source: Chinese Journal of Chemistry

DOI: 10.1002/cjoc.70197

Authors: Zi‐Han Wang, Hui Zhu, Rui‐Xue Liu, Yu‐Xuan Liu, Xin‐Chen Liu, Tao‐Yan Lin

Institutions: Huaibei Normal University, Guizhou University

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Award: G1095769963