Work

Mannose-decorated polymersomes loaded with antigens and TLR7/8 agonists targeting antigen-presenting cells for enhancing vaccine efficacy

Year: 2025

Type: article

Abstract: Mannose-decorated polymersomes co-encapsulating OVA and the TLR7/8 agonist R848 target mannose-receptor on APCs, promoting enhanced antigen uptake, APC maturation, cross-presentation, and robust cellular and humoral immune responses.

Source: Materials Advances

DOI: 10.1039/d5ma00115c

Authors: Jong-Woo Lim, So-Eun Lee, Hongjun Park, Sojeong Lee, Minjoo Yeom, Seungjoo Haam, Daesub Song

Institutions: Seoul National University, Research Institute for Veterinary Science, Yonsei University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: National Research Foundation, Korea Research Institute of Bioscience and Biotechnology, National Research Foundation of Korea, Ministry of Science and ICT, South Korea

Awards: G1164051584, G3348809697, G391247316

OpenAlex ID: W4412919816

FWCI: 1.22

Cites: 39

Cited by: 4

Related to: 10