Work

Gait Kinematics of Individuals with SYNGAP1-Related Disorder Compared with Age-Matched Neurotypical Individuals

Year: 2025

Type: article

Abstract: SYNGAP1-related disorder is a rare neurodevelopmental disorder characterized by intellectual and motor disabilities, including disordered gait control. Currently, there have been few studies that have assessed the gait of individuals with SYNGAP1-related disorder using technology-based collection techniques. The purpose of this investigation was to characterize the kinematic gait pattern of these individuals using camera-based motion capture technology during treadmill walking. Both linear and non-linear analysis techniques were used to analyze bilateral lower-limb joint motion and compare the results to age-matched neurotypical individuals. Results indicate that joint range of motion and velocity were decreased in the patient population relative to the neurotypical participants with the non-linear measures of angle–angle and phase portrait areas reflecting similar outcomes. The combination of linear and non-linear measures provide complementary information that, when used in combination, can provide deeper insights into the coordination and control of gait than if either of the measurement techniques are used in isolation. Such information can be useful to clinicians and therapists to develop targeted interventions designed to improve the gait of individuals with SYNGAP1-related disorder.

Source: Applied Sciences

DOI: 10.3390/app15158267

Authors: Charles S. Layne, Dacia Martinez Diaz, Christopher A. Malaya, Bernhard Suter, Jimmy Lloyd Holder

Institutions: University of Houston, Parker University, Baylor College of Medicine, Texas Children's Hospital

Language: English

Topic: Balance, Gait, and Falls Prevention

Subfield: Physical Therapy, Sports Therapy and Rehabilitation

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896