Diagnostic value of mucosal-associated invariant T+ cells combined with inflammatory factors in differentiating chronic rhinosinusitis subtypes with or without nasal polyps
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The present study attempted to analyze the effect of mucosal-associated invariant T (MAIT) combined with inflammatory factors in identifying chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) that provides a clinical reference. Methods: In this retrospective study, we enrolled 56 CRSsNP patients, 68 CRSwNP patients, and 64 healthy controls. Flow cytometry was used to detect the frequency of peripheral blood MAIT+ cells (MAIT+). Serum levels of hs-CRP, IL-ip, and IL-6 were measured by ELISA and automatic blood cell analyzer, and their correlations with MAIT cell alterations were analyzed. The diagnostic effect of MAIT+ combined with hs-CRP IL-ip, and IL-6 on CRS was analyzed using ROC curves. Results: Both CRSsNP and CRSwNP patients exhibited significantly reduced MAIT+ frequencies compared to controls (P< 0.05), with CRSwNP showing the most pronounced decrease (P < 0.0 5). MAIT+ frequency was inversely correlated with hs-CRP IL-ip, and IL-6 in CRS patients. ROC analysis demonstrated that MAIT+ effectively discriminated CRSsNP (AU C= 0.793) and CRSwNP (AU C= 0.863) from healthy individuals (P< 0.01). After combined with inflammatory factors, the diagnostic effect of MAIT+ combined inflammatory factors on CRSsNP (AU C= 0.933) and CRSwNP (AU C= 0.939) was further improved. Conclusions: Detection of MAIT+ combined with inflammatory factors may provide potential biomarkers for CRS subtype identification.
Source: Journal of Medical Biochemistry
DOI: 10.5937/jomb0-59840
Authors: Yilong Wang, Yongjun Feng, Jie Song, Zhonglin Mou
Institution: Hainan Medical University
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412922092