Comparison of Fractionated Dose Versus Bolus Dose of Hyperbaric Bupivacaine Injection in Spinal Anesthesia: Hemodynamic Stability in Elderly Patients Undergoing Lower Limb Surgeries
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: BACKGROUND: Spinal anesthesia (SA) with a bolus dose provides a rapid onset but often leads to hemodynamic instability, particularly in elderly patients. Fractionated dosing of hyperbaric bupivacaine may offer a dense block with greater stability and prolonged analgesia. This study compares the effects of bolus and fractionated dosing on hemodynamic parameters in elderly patients undergoing lower limb surgeries. METHODS: In this randomized controlled trial, 60 elderly patients (n=60 patients; 30 patients per group) of more than 60 years were randomly assigned to receive either a bolus dose (Group B) or fractionated doses (Group F) of hyperbaric bupivacaine for SA. Intraoperative monitoring included blood pressure, heart rate, oxygen saturation, and ECG. Hemodynamic parameters were analyzed at serial intervals up to 180 minutes. RESULTS: Demographic and baseline parameters were comparable between groups. A statistically significant difference in mean arterial pressure (MAP) and diastolic blood pressure (DBP) was observed only at 90 minutes post-anesthesia (MAP: Group F 90.71 mmHg vs. Group B 84.63 mmHg, p = 0.043; DBP: Group F 74.90 mmHg vs. Group B 69.04 mmHg, p = 0.025). The fractionated group required fewer vasopressor interventions (p = 0.001). CONCLUSION: Fractionated dosing of hyperbaric bupivacaine in SA demonstrated improved hemodynamic stability at specific time points and reduced vasopressor requirements in elderly patients. However, due to limited power and isolated significance, further large-scale, blinded studies are needed to confirm the clinical relevance of fractionated dosing in elderly patients.
Source: Cureus
DOI: 10.7759/cureus.88714
Authors: Shailesh Mishra, Neha Dubey, Akash Verma, Shalini Sahu
Institution: People’s University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412922884