Work

Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors

Year: 2025

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2025.118021

Authors: Najah Albadari, Yang Xie, Qinghui Wang, Darcie J. Miller, Judith Quadrozzi Gruntz, Michael L. Oldham, Hao Chen, Dejian Ma, Zhongzhi Wu, Duane D. Miller, Wei Li

Institutions: University of Tennessee Health Science Center, University of Ha'il, University of California, San Francisco, St. Jude Children's Research Hospital

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Drug Discovery Center, College of Pharmacy, Health Science Center, University of Tennessee, U.S. Department of Energy, Conseil National de la Recherche Scientifique, Centro de Ecológia Aplicada, National Institutes of Health, Office of Science, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources, Biological and Environmental Research

Awards: G1867732070, G278818165, Acquisition of a Q-TOF Mass Spectrometer, Acquisition of a 400MHz Solution NMR System with an Autosampler, G8775485830, Center for Biomolecular Structure (CBMS), Targeting the colchicine binding site in tubulin for cancer therapy

OpenAlex ID: W4412937848

FWCI: 1.414

Cites: 48

Cited by: 5

Related to: 10