Work

CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription

Year: 2025

Type: article

Abstract: Our findings highlight CREPT as a pivotal regulator of LUAD progression and suggest it could be a potential therapeutic target for patients with EGFR or KRAS mutations insensitive or resistant to targeted therapies.

Source: Theranostics

DOI: 10.7150/thno.115572

Authors: Mengdi Li, Yuting Lin, Jiayu Wang, He Yang, Danhui Ma, Ye Tian, Yi Wang, Liu Yang, Umar Farooq, Yinyin Wang, Fangli Ren, Jian Sheng, Guoqing Zhang, Liang Chen, Jun Li, Xiangnan Li, Zhijie Chang

Institutions: State Key Laboratory of Membrane Biology, Tsinghua University, Beijing Tsinghua Chang Gung Hospital, Jinfeng Laboratory, Jiaxing University, First Affiliated Hospital of Zhengzhou University, Jinan University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4412943453

FWCI: 2.942

Cites: 50

Cited by: 5

Related to: 10