Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis.
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Background/objectives: Recent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the potential relationship between these two conditions. Methods: A comprehensive literature search was conducted across PubMed, Embase, and Web of Science from their inception until January 2025 to identify observational studies examining the association between atopic dermatitis and stroke risk. Random-effects meta-analyses were performed using the generic inverse variance method, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Additionally, sensitivity analyses and subgroup analyses were conducted to assess the stability of the results and explore potential sources of heterogeneity. Results: = 5, OR = 1.14 95%CI = 1.00-1.30). Furthermore, sensitivity analyses demonstrated that the results were stable and reliable. Conclusion: AD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD. Systematic review registration: Identifier INPLASY202550006.
Source: PubMed
Authors: Hong Pan, Qing-Ping Han, Min-Ling Zeng, Fang Wang, Ying Xiong, Bo Wu, Hai-Ying Yu
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412957304