The clinical value of immune cell composition in the diagnosis of pediatric sepsis.
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The objective of this study was to evaluate the diagnostic significance of various immune cell ratios in children with sepsis via the analysis of clinical data. Methods: < 0.05. Result: < 0.001). ROC analysis identified NLR [The area under the ROC curve (AUC) = 0.932], PLR (AUC = 0.907), and NLPR (AUC = 0.848) as effective immune ratio biomarkers, while MLR (AUC = 0.784) showed limited utility. Among laboratory tests, WBC (AUC = 0.902), neutrophils (AUC = 0.919), CRP (AUC = 0.923), PLT (AUC = 0.879), and ESR (AUC = 0.875) demonstrated strong diagnostic accuracy, whereas lymphocyte, monocyte, and hemoglobin levels were less discriminative. Conclusion: Our study reveals that combining immune cell ratios and CRP significantly enhances early detection of pediatric sepsis, improving clinical outcomes.
Source: PubMed
Authors: Jie Shen, Qing Zhong, Jing Su, Xuan Shen, Wenya Li, Tianyu Sun, Yaoyun Zhang, Jijin Qi
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412957680