An Active Silicon Perforated Mea for Seamless 3D Organoid Interfacing with Low-Noise, Scalable Multimodal Electrophysiology
Year: 2025
Type: conference-paper
Abstract: We present the first active silicon perforated MEA for 3D organoid interfacing, integrating CMOS electronics for lownoise, high-resolution recording, stimulation, and impedance spectroscopy (EIS) across 7 modalities. The MEA, fabricated in 130 nm CMOS technology, features a scalable 256 -island mesh with multiplexed operation, achieving low input-referred noise ($9.1 \pm 1.5 \mu \mathrm{V}_{\text {rms }}, 300 \text{Hz}-10 \text{kHz}$) and low power ($11.3 \mu \mathrm{W}$per island). In vitro tests with cardiomyocytes demonstrate accurate recordings, network propagation mapping, and intracellular recordings via voltage stimulation. This perforated MEA offers unparalleled functionality and scalability for advancing organ-on-chip research.
Authors: Aitor Rivero-Cortazar, Joan Aymerich, Sohail Faizan Shaikh, Andrea Lodi, Bogdan Raducanu, Georges Gielen, Carolina Mora Lopez
Institution: IMEC
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funder: Fonds Wetenschappelijk Onderzoek
OpenAlex ID: W4412964825