Cross-tissue omics-guided drug repurposing triangulates novel targetable mechanisms for Alzheimer’s disease and candidate genetic biomarkers for treatment stratification
Year: 2025
Type: preprint
Source: Research Square
Authors: Sathyaseelan Chakkarai, Michal Sadowski, Qiong Yang, Anushree Ray, Ruiqi Wang, Laurent F. Thomas, Raquel Puerta Fuentes, Mohsen Sharifi Tabar, Biqi Cui, Xueqiu Jian, Paul A. Nyquist, Dipender Gill, Allison E. Aiello, Thomas J. Montine, Syed Bukhari, Emily Rogalski, Steve E. Edland, Mary E. Haan, Claudia H. Kawas, Maria M. Corrada, Arash Salardini, Zsu-Zsu Chen, Jayandra Jung Himali, Claudia L. Satizabal, Robert E Gerszten, Bjørn Olav Åsvold, Myriam Fornage, Carlos Cruchaga, Mohamad Habes, Daniel I. Chasman, Lenore J. Launer, Margaret E. Flanagan, Ben Michael Brumpton, Marios K Georgakis, Noah Zaitlen, Agustin Ruiz, Stéphanie Debette, Sudha Seshadri, Muralidharan Sargurupremraj
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Studying transposable elements abundance in Alzheimer’s disease brains, G9000112075, G9000189329, G9000197461, G9000205596, G9000222412, G9000262527, G9000290608, G9000311169, Computational Genomics Summer Institute and Mentoring Network, The pathogenic effects of senescent cells on their microenvironments and their role in human brain aging
OpenAlex ID: W4412975064