Work

Photobiomodulation mitigates LPS-induced astrocyte neuroinflammation via the STAT5A/SOCS3 axis

Year: 2025

Type: article

Abstract: Neuroinflammation plays an important role in the occurrence and development of neurological diseases. In addition to microglia, the role of astrocytes in neuroinflammation has gradually attracted attention. Photobiomodulation (PBM), as a non-invasive treatment, has been shown potential to alleviate inflammation of microglia or astrocytes. In this study, the spatiotemporal regulation and molecular mechanism of PBM on astrocytes were deeply explored by analyzing the effects and genomics at different time points. The results showed that PBM significantly attenuated the upregulation of inflammatory factors and mitochondrial dysfunction in astrocytes under LPS stimulation for 4[Formula: see text]h and 24[Formula: see text]h. RNA-seq analysis showed that the JAK-STAT pathway played an important role in the early stage of both LPS-induced astrocytic neuroinflammation and PBM-alleviated astrocytic neuroinflammation. Under PBM treatment, Stat5a translocation to the nucleus and upregulated Socs3 expression were observed in LPS-treated astrocytes, which may inhibit the overactivation of the JAK-STAT inflammatory signaling pathway and thus alleviate astrocyte inflammation. Taken together, this study provides new insight into the molecular mechanism of the potential application of PBM in the treatment of neuroinflammation.

Source: Journal of Innovative Optical Health Sciences

DOI: 10.1142/s1793545825500282

Authors: Wenjing Chen, Xiaotong Gu, Shengnan Wu, Feifan Zhou

Institutions: Hainan University, Beijing Institute of Technology

Language: English

Topic: Laser Applications in Dentistry and Medicine

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500