Year: 2024
Type: article
Abstract: Aim of this work is to verify the acid lable , gastro irritants APIs for oral subministration and the active molecule that need a specific enteric release. This information are useful in galenic field in order to choose the best veicle (for oral suspension or solution ) and the right kind of capsules ( normal or with gastroresistance ). In this article not all molecules are analyzed , only submitted significative example. Some formulation are reported that require specific PH or enteric release or based on lightly water soluble API. Various charcteristics of some commercial product ( veicle for oral suspension) are reported only to show the composition and the rationale of their use : the reason to use one veicle for ph 4 or for buffered at ph 7-8 or and related the capsules : use of normal or AR or treated for gastroresistence - enteric coating. The chemico-phisical properties of the active principle are crucial to choose the right veicle for oral suspension or the kind of capsules ( gastroresistence or not ) . Fundamental for this approach the physiology of the Ph variation along the GI apparatus .
Author: Luisetto M
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4412979179