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Rare Cutaneous Metastasis of Endometrial Carcinoma: A Sister Mary Joseph Nodule

Year: 2025

Type: article

Abstract: Sister Mary Joseph nodules are cutaneous evidence of umbilical metastasis from an abdominal or pelvic primary neoplasm. They typically present as a firm, tender, irregular mass with evidence of serous or purulent discharge ranging in size from 0.5 cm all the way up 10 cm. This case describes a rare presentation of Stage IV B, Grade 2 endometrioid carcinoma of the endometrium as a Sister Mary Joseph nodule in an 82-year-old nulliparous woman. While the pathophysiology of these lesions is poorly understood, early recognition of these nodules aids in decreasing time to diagnostic work-up and treatment.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0398

Authors: Matthew R. Corn, Chad H. Martins

Institutions: Mercer University, Mercer University Health Sciences Center, Memorial Health University Medical Center

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412983040

FWCI:

Cites: 2

Cited by:

Related to: 10