Aminoquinoline-directed electro/Ni dual-catalyzed C(sp2)-H alkylation with alkyl bromides
Year: 2025
Type: article
Abstract: ABSTRACT Paired electrolysis offers an attractive platform for organic synthesis of avoiding the sacrificial anode. In this work, we developed a methodology of N,N' -bidentate aminoquinoline assistant-directed electro/Ni dual-catalyzed C( sp 2 )-H alkylation with alkyl bromides under the paired electrolysis. The alkyl radicals are generated from dehalogenation of the bromoalkanes by α -aminoalkyl radical formed in situ from oxidation of tertiary amine at the anode, which have been captured by the reactive intermediates of Ni-complex formed by coordination/C( sp 2 )-H activation sequences at the cathode, and then reductive elimination to give alkylation products. This method proceeded in mild reaction conditions, avoided sacrificial anode materials, and afforded 26%-89% yields. The reaction mechanism was studied through cyclic voltammetry and controlled experiments.
Source: Green Synthesis and Catalysis
Authors: Rui Liu, Xiaoyu Zhan, Guihua Chen, Yungui Peng
Institution: Southwest University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funder: Southwest University
Award: G253075812
OpenAlex ID: W4412988785