Correlation Between Serum Biomarkers and Intracompartmental Pressure in Diagnosing Acute Compartment Syndrome in Leg Fractures
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Acute Compartment Syndrome (ACS) is a serious complication of leg fractures that requires timely diagnosis and intervention.While intracompartmental pressure monitoring remains the gold standard for diagnosis, the role of serum biomarkers as non-invasive diagnostic tools is gaining interest.This study investigates the correlation between serum biomarkers and intracompartmental pressure in diagnosing ACS.To evaluate the correlation of serum biomarkers with compartment pressure monitoring in suspected ACS in fractures of the leg and its medico-legal significance. Materials and Methods:This prospective observational study included 60 patients with leg fractures suspected of developing ACS.Serum biomarkers were measured, including creatine kinase, potassium, lactate, bicarbonate, and chloride.Simultaneously, intracompartmental pressure was recorded using a pressure monitoring device.Data were analysed using descriptive statistics, correlation coefficients, and binary logistic regression to evaluate the association of biomarkers with intracompartmental pressure.Results: Serum biomarkers, particularly creatine kinase and lactate, offer valuable support in diagnosing ACS in leg fractures, complementing intracompartmental pressure monitoring.Integrating these biomarkers into diagnostic protocols can improve early detection, especially in resource-limited settings.This research underscores the medico-legal significance, as accurate ACS identification prevents legal issues arising from delayed intervention and patient harm.Conclusion: Serum biomarkers, particularly creatine kinase and lactate, show promise as adjuncts to intracompartmental pressure monitoring for diagnosing ACS in leg fractures.Incorporating these biomarkers into diagnostic protocols may enhance early detection, particularly in resource-limited settings.Further studies are needed to validate these findings and establish clinical thresholds.This research highlights the medico-legal significance of serum biomarkers in diagnosing ACS in leg fractures.Elevated creatine kinase and lactate levels, along with clinical findings, provide crucial evidence for timely diagnosis and treatment.Accurate identification of ACS can prevent legal implications related to delayed intervention and patient harm.
Source: Comprehensive Medicine
Author: Saurabh Jha
Institution: Dr. Ram Manohar Lohia Institute of Medical Sciences
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412992143