Treatment strategies and palliative care in advanced non-HIV Kaposi’s sarcoma: case study and literature review
Year: 2025
Type: article
Abstract: Non-HIV Kaposi’s sarcoma is a rare angioproliferative tumor with variable progression, but characterized by marked aggressiveness due to its capacity for locoregional recurrence. The therapeutic management of advanced classic Kaposi’s sarcoma (CKS) is challenging because, although radiotherapy effectively controls local lesions, the aggressive progression, characterized by frequent locoregional recurrences, leads to the inability to administer effective local therapy. Systemic chemotherapy with pegylated liposomal doxorubicin helps control distant disease dissemination, but the therapeutic responses remain suboptimal. To illustrate the disease progression and locoregional aggressiveness, we present the case of a 76-year-old patient diagnosed with classic Kaposi’s sarcoma in 2010, without HIV infection, but with multiple comorbidities, who, between 2012 and 2024, underwent radiotherapy with an initially favorable response, followed by frequent recurrences. The treatment of advanced CKS requires a personalized approach, with radiotherapy remaining the primary therapeutic strategy, yet frequent recurrences highlight the limitations of current therapies, emphasizing the importance of palliative care and the need for innovative therapeutic strategies.
Source: Oncolog-Hematolog ro
Authors: Oana Rusu, Virgil Pătrașcu, Răzvan Bălan, Anda-Elena Crișan
Institution: University of Medicine and Pharmacy of Craiova
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412995363