Work

Bottom-up sono-enzymatic approach to build antimicrobial and antifouling nano-enabled coatings on urinary catheters

Year: 2025

Type: article

Abstract: after 24 h. Contact angle measurements confirmed surface hydrophilicity (≈85°) of GaCeNPs_pSB-coated silicone for at least 7 days. Biofilm formation on Foley catheters functionalised with GaCeNPs_pSB was reduced by 70% upon incubation for a week in an artificial bladder model with continuous recirculation of infected urine. No adverse effects on fibroblast viability were observed over the same period of time in contact with the coated silicones, demonstrating their excellent biocompatibility (>90%). Altogether, this sono-enzymatically engineered, bio-based coating offers a promising strategy to reduce bacterial colonisation and biofilm formation on urinary indwelling devices and consequently the risk of infection in catheterised patients.

Source: Nanoscale Advances

DOI: 10.1039/d5na00577a

Authors: Antonio Puertas-Segura, Leonardo Martín Pérez, Paul Savage, Kristina Ivanova, Gianluca Ciardelli, Tzanko Tzanov

Institutions: Universitat Politècnica de Catalunya, Brigham Young University, Politecnico di Torino

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962