Work

Catalyzed [2+2]-Cycloaddition Reactions of Hexafluoroisopropyl 4-Chloro-2-oxobut-3-ynoate with Simple Alkenes

Year: 2025

Type: article

Abstract: It is shown for the first time that the [2+2]-cycloaddition reactions of hexafluoroisopropyl 4-chloro-2-oxobut-3-ynoate with simple alkenes, proceeding sluggishly in an excess of alkenes or in usual solvents, are strongly improved by hexafluoroisopropanol (HFIP). The yields of the target products also increase compared to the conventional methods. A general protocol for performing such transformations has been developed.

Source: INEOS OPEN

DOI: 10.32931/io2527a

Authors: A. B. Koldobskii, A. A. Druzina, O. S. Shilova, O. A. Kizas

Institutions: Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Ministry of Science and Higher Education of the Russian Federation

Award: G160288408