Year: 2025
Type: conference-paper
Abstract: Multi-channel solid-state nanopores can be used to detect biological macromolecules such as DNA, RNA and proteins, enabling sequencing, structural characterization and other studies by analyzing the signal characteristics of the over-well currents of these markers. Aiming at the increasing requirements of large-scale sequencing, a portable and high-throughput integrated sequencing device is designed, which can realize signal extraction, processing, recognition, display, storage and transmission. Among them, the solid-state nanopore sensor can extract current signals from four channels, and the current extraction and integral amplification module of the back-end circuit will amplify the current at nA level to the voltage at mV level, while controlling the noise at μV/(Hz)1/2 level.
Authors: Wenhui Zhang, Jiuxu Zhu, Chongxin Tao, Liqing Wang, Rumo Pan, Jian Li
Institution: Southeast University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Awards: G1651696827, G368688443, G715636683
OpenAlex ID: W4413008230